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MOG(1-125) Protein, Human

$2,061.00
$2,061.00
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Limited-Time Offers, End in: 151D 8H 23M 0S
Size: 500μg
Subtotal: $2,061.00

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Size Guide

Understanding Mylulusstore Sizing
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MOG(1-125) Protein, Human

$2,061.00
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MOG(1-125) Protein, Human

$2,061.00
Size: 500μg
Description
Description
x

Product Specification


Species Human, Human
Antigen MOG
Synonyms MOG,BTN6,BTNL11,MOGIG2,NRCLP7,Myelin oligodendrocyte glycoprotein
Accession Q16653
Amino Acid Sequence

Gly30-Gly154, with C-terminal 8*His

Expression System HEK293
Molecular Weight

20-23kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1. Reindl, M. et al. (2013) Nat. Rev. Neurol. 9:455.

Background

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily. Mouse MOG is synthesized with a 28 amino acid (aa) signal sequence, a 128 aa extracellular domain (ECD) containing an Ig-like domain, a 21 aa transmembrane domain, and a 69 aa cytosolic fragment featuring a hydrophobic domain that associates with the cytoplasmic face of the plasma membrane. MOG is expressed exclusively by oligodendrocytes in the central nervous system (CNS) and is localized to the outer layer of the myelin sheath as well as in the oligodendrocyte plasma membrane. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases.

Guidelines

Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in 
central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was 
demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune 
encephalomyelitis (EAE) in rodents and monkeys (1-5). 
The purified human rMOG is recommended for in vitro studies such as T cell and B cell responses, cytokine response, 
antigen presentation, Western blotting, and ELISA as well as for in vivo study such as EAE induction in mice and monkeys. 
The following dosages are recommended: 5-20 μg/ml for in vitro study and 50-100 μg per animal for in vivo study

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