{"product_id":"mog1-125-protein-human","title":"MOG(1-125) Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e \u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eHuman, Human\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eMOG\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eMOG,BTN6,BTNL11,MOGIG2,NRCLP7,Myelin oligodendrocyte glycoprotein\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eQ16653\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eGly30-Gly154, with C-terminal 8*His \u003c\/p\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e20-23kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u0026gt;95% by SDS-PAGE\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003ePBS, pH7.4\u003c\/p\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/p\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e \u003cp style=\"margin-bottom: 0px;\"\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/p\u003e \u003cp style=\"margin-bottom: 0px;\"\u003e · 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/p\u003e \u003cp style=\"margin-bottom: 0px;\"\u003e · 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/p\u003e \u003cp style=\"margin-bottom: 0px;\"\u003e · Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e \u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e1. Reindl, M. et al. (2013) Nat. Rev. Neurol. 9:455.\u003c\/p\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003c\/tbody\u003e\u003c\/table\u003e \u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eMyelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily. Mouse MOG is synthesized with a 28 amino acid (aa) signal sequence, a 128 aa extracellular domain (ECD) containing an Ig-like domain, a 21 aa transmembrane domain, and a 69 aa cytosolic fragment featuring a hydrophobic domain that associates with the cytoplasmic face of the plasma membrane. MOG is expressed exclusively by oligodendrocytes in the central nervous system (CNS) and is localized to the outer layer of the myelin sheath as well as in the oligodendrocyte plasma membrane. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases.\u003c\/p\u003e\u003c\/div\u003e\u003ch4\u003eGuidelines\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in \u003cbr\u003ecentral nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was \u003cbr\u003edemonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune \u003cbr\u003eencephalomyelitis (EAE) in rodents and monkeys (1-5). \u003cbr\u003eThe purified human rMOG is recommended for in vitro studies such as T cell and B cell responses, cytokine response, \u003cbr\u003eantigen presentation, Western blotting, and ELISA as well as for in vivo study such as EAE induction in mice and monkeys. \u003cbr\u003eThe following dosages are recommended: 5-20 μg\/ml for in vitro study and 50-100 μg per animal for in vivo study\u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"500μg","offer_id":41276509651008,"sku":null,"price":2061.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":41276509683776,"sku":null,"price":3101.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/6342\/4320\/files\/d804a28d-40a7-43c2-895c-52c6662009e4_37889eef-0a5e-4492-b049-c5347480b231.png?v=1782030907","url":"https:\/\/wearvico.com\/products\/mog1-125-protein-human","provider":"wearvico","version":"1.0","type":"link"}